Activities

Publications

Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. A Bertolino, L Fazio, A Di Giorgio, G Blasi, R Romano, P Taurisano, G Caforio, L Sinibaldi, G Ursini, T Popolizio, E Tirotta, A Papp, B Dallapiccola, E Borrelli, W Sadee. J Neurosci 29:1124-1234, 2009.

Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins. AN Pham, J Wang, J Fang, X Gao, Y Zhang, PE Blower, W Sadee, Y Huang. Pharm Res 26:936-945, 2009. Epub 2008 Dec 10.

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia. BA Bertolino, L Faxio, G Cafori, G Blasi, A Rampino, R Romano, A Di Giorgio, P Taurisano, A Papp, J Pinsonneault, D Wang, M Nardini, T Popolizio, W Sadee. Brain 132:417-425, 2009. Epub 2008 Oct 1.

Drug therapy and personalized health care: pharmacogenomics in perspective. W Sadee. Pharm Res 25:2713-2719, 2008. Epub 2008 Aug 26.

microRNAs modulate the chemosensitivity of tumor cells. PE Blower, J-H Chung, JS Verducci, S Lin, J-K Park, Z Dai, C-G Liu, TD Schmittgen, WC Reinhold, CM Croce, JN Weinstein, W Sadee. Molec Cancer Therap 7:1-9, 2008.

Genotyping panel for assessing response to cancer chemotherapy. Z Dai, AC Papp, D Wang, H Hample, W Sadee. BMC Med Genomics. 1:24, 2008. http://www.biomedcentral.com/1755-8794/1/24.

The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lun epithelia. B Besecker, S Bao, B Bohacova, A Papp, W Sadee, D Knoell. Amer J Physiol, in press, 2008.

Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. AD Johnson, Y Zhang, AC Papp, JK Pinsonneault, J-E Lim, D Saffen, Z Dai, D Wang, W Sadee. Pharmacogen Genom, 18:781-791, 2008.

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. D Wang, H Chen, KM Momary, LH Cavallari, JA Johnson, W Sadee. Blood, 112:1013-1021, 2008. Epub 2008 June 3. Erratum in Blood 113:1393-1394, 2009.

Novel polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Y Zhang, A Bertolino, L Fazio, G Blasi, A Rampino, R Romano, M-LT Lee, T Xiao, A Papp, D Wang, W Sadee. Proc Natl Acad Sci USA 104:20552-20557, 2007.

Cystine-glutamate transporters SLC7A11 mediates resistance to geldanamycin but not to 17-AAAG. R Liu, PE Blower, A-N Pharm, J Fang, Z Dai, C Wise, B Green, CH Teitel, B Ning, W Ling, BD Lyn-Cook, FF Kadlubar, W Sadee, Y Huang. Molec Pharmacol 72:1637-1646, 2007.

MicroRNA expression profiles for the NCI-60 cancer cell panel. PE Blower, JS Verducci, S Lin, J Zhou, J-H Chung, Z Dai, C-G Liu, W Reinhold, PL Lorenzi, EP Kaldijian, CM Croce, JN Weinstein, W Sadee. Mol Cancer Ther 6:1483-1491, 2007.

Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1. Y Huang, PE Blower, Z Dai, H Moon, J Fang, W Sadee. Pharm Res 24:1702-1712, 2007.

KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the International Verapamil SR/Trandolapril Study (INVEST). AL Beitelshees, Y Gong, D Wang, NJ Schork, RM Cooper-Dehoff, TY Langaee, MD Shriver, W Sadee, CJ Pepine, JA Johnson. Pharmacogen Genomics 17:719-729, 2007.

Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system ^x-c. Z Dai, Y Huang, W Sadee, P Blower. J Med Chem 15:1896-1906, 2007.

Different effects of opioid antagonists on mu, delta, and kappa opioid receptors with and without agonist pretreatment. D Wang, X Sun, W Sadee. J Pharmacol Exp Ther 321:544-552, 2007.

Chemogenomics of sensitivity and resistance to anticancer drugs. Z Dai, W Sadee, P Blower. Curr Pharmacogenom 5:11-19, 2007.

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. J-E Lim, J Pinsonneault, W Sadee, D Saffen. Molec Psychiatry 12:491-501, 2007.

Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. X Cao, L Fang, S Gibbs, Y Huang, Z Dai, P Wen, X Zheng, W Sadee, D Sun. Cancer Chemother Pharmacol 59:495-505, 2007.

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. J-E Lim, J Pinsonneault, W Sadee, D Saffen. Molec Psychiatry, 12:491-501, 2007.

Prediction of anticancer drug potency from expression of genes involved in growth factor signaling. Z Dai, C Barbacioru, Y Huang, W Sadee. Pharm Res 23:337-349, 2006.

Genetic variants of the human dipeptide transporter PEPT1. P Anderle, CU Nielsen, J Pinsonneault, P Lindskov Krog, B Brodin, W Sadee. J Pharmacol Exp Ther 316:636-646, 2006.

Allelic expression of serotonin transporter (SERT) mRNA in human pons: Lack of correlation with the polymorphism SERTLPR. J-E Lim, A Papp, J Pinsonneault, W Sadee, D Saffen. Molec Psychiatry 11:649-669, 2006.

Protein therapeutics - New applications for pharmacogenetics. C Krejsa, M Rogge, W Sadee. Nature Rev Drug Disc 5:507-521, 2006.

Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C (CACNA1C) in human heart tissues. D Wang, AC Papp, PF Binkley, AD Johnson, W Sadee. Pharmacogen Genomics 16:735-745, 2006.

Proteomic profiling of cancer cell line EKVX treated with the combination of a chemotherapeutic drug and a small molecule inhibitor. Y Wang, Z Dai, W Sadee, WS Hancock. Mol Pharmaceut 3:566-578, 2006.

Allelic mRNA expression of X-linked monoamine oxidase A (MAOA) in human brain: Dissection of epigenetic and genetic factors. JK Pinsonneault, AC Papp, W Sadee. Hum Molec Genet 15:2636-2649, 2006.

Polymorphisms affecting gene regulation and mRNA processing: Broad implications for pharmacogenetics. AD Johnson, D Wang, W Sadee. Pharmacol Ther 106:19-38, 2005.

Correlating gene expression with chemical scaffolds of cytotoxic agents: Ellipticines as substrates and inhibitors of MDR1. Y Huang, PE Blower, C Yang, C Barbacioru, Z Dai, Y Zhang, JJ Xiao, KK Chan, W Sadee. Pharmacogenomics J 5:112-125, 2005.

Strategies and methods for research on sex differences in brain and behavior. JD Becker, A Arnold, KJ Berkeley, JD Blaustein, L Eckel, E Hampson, JP Herman, S Mart, W Sadee, J Taylor, E Young. Endocrin 146:1650-1673, 2005.

Efflux of depsipeptide FK228 (FR091228, NSC-630176) is mediated by both P-glycoprotein and MRP1. JJ Xiao, AB Foraker, PW Swaan, S Liu, Y Huang, Z Dai, J Chen, W Sadee, J Byrd, G Marcucci, KK Chan KK. J Pharmacol Exp Ther 313:268-276, 2005.

ABCB5-Mediated doxorubicin transport and chemoresistance in human malignant melanoma. NY Frank, A Margaryan, T Schatton, Y Huang, AM Waaga-Gasser, M Gasser, MH Sayegh, W Sadee, MH Frank. Cancer Res 65:4320-4333, 2005.

Cystine/glutamate transporter SLC7A11 in cancer chemosensitivity and -resistance. Y Huang, Z Dai, C Barbacioru, Sadee W. Cancer Res 65:7446-7454, 2005.

Pharmacogenomics: Harbinger for the era of personalized medicine? W. Sadee. Molec Interventions 5:140-143, 2005.

Pharmacogentics/genomics and personalized medicine. W Sadee, Z Dai. Hum Mol Genet 14:R207-R214, 2005.

Multidrug resistance polypeptide 1 (MDR1, ABCB1) Variant 3435C> T affects mRNA stability. D Wang, AD Johnson, A Papp, DL Kroetz, W Sadee. Pharmacogen Genomics 15:693-704, 2005.

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. Y Zhang, D Wang, AD Johnson, AC Papp, W Sadee. J Biol Chem 280: 32618-32624, 2005.

Growth factor signaling and resistance to cancer chemotherapy. Z Dai, Y Huang, W Sadee. Curr Top Med Chem 4:1347-1356, 2004.

Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance. Y Huang, P Anderle, KJ Bussey, C Barbacioru, U Shankavaram, Z Dai, WC Reinhold, A Papp, JN Weinstein, W Sadee. Cancer Res 64:4294-4301, 2004.

Genetic variants of the human H+/dipeptide transporter PEPT2: Analysis of haplotype functions. J Pinsonneault, CU Nielsen, W Sadee. J Pharmacol Exp Ther 311:1096-1098, 2004.

Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance. Y Huang, P Anderle, KJ Bussey, C Barbacioru, U Shankavaram, Z Dai, WC Reinhold, A Papp, JN Weinstein, W Sadee. Cancer Res 64:4294-4301, 2004.

Genetic variants of the human H+/dipeptide transporter PEPT2: Analysis of haplotype functions. J Pinsonneault, CU Nielsen, W Sadee. J Pharmacol Exp Ther 311:1096-1098, 2004.

A meta-analysis of studies on the association of the platelet PIA polymorphism of glycoprotein IIIa and risk of coronary heart disease. D Burr, H Doss, GE Cooke, PJ Goldschmidt-Clermont. Statist Med 22:1741-1760, 2003.

Drug sensitivity and resistance genes in cancer chemotherapy: A chemogenomomics approach. Y Huang, W Sadee. Drug Discovery Today 8:356-363, 2003.

Single nucleotide polymorphism genotyping using allele-specific PCR and fluorescence melting curves. AC Papp, JK Pinsonneault, G Cooke, W Sadee. Bio Techniques 34:1067-1072, 2003.

Differential effects of u opioid receptor (MOR) ligands on Ca2+ signaling. JM Quillan, KW Carlson, C Song, D Wang W Sadee. J Pharmacol Exp Ther 302:1002-1012, 2002.

HIV-1 infection and AIDS dementia are influenced by a mutant of MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. E Gonzalez, BH Rovin, L Sen, G Cooke, et al. PNAS 99:1375-13800, 2002.

The PIA polymorphism of glycoprotein IIIa functions as a modifier for the effect of estrogen on platelet aggregation. KD Boudoulas, GE Cooke, CM Roos, et al. Arch Pathol Lab Med 125:112-115, 2001.

Mu opioid receptor-mediated ERK-activation involves calmodulin-dependent EGF receptor transactivation. MM Belcheva, M Szucs, D Wang, W Sadee, CJ Coscia. J Biol Chem 276:33847-3353, 2001.

Single nucleotide polymorphisms in the human u opioid receptor gene alter G protein coupling and calmodulin binding. D Wang, JM Quillan, K Winans, JL Lucas, W Sadee. J Biol Chem 276:34624-34630, 2001.

Priming of platelet AIIb?3 by oxidants associated with tyrosine phosphorylation ?3. K Iran, Y Pham, LD Coleman, C Roos, GE Cooke, et al. Arterioscler Thromb Vasc Biol 18:1698-1706, 1988.