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Pharmacogenomics Core Laboratory


Pharmacogenomics Core Laboratory (Head: Audrey Papp)

 

The core laboratory serves to support collaborative research projects.  The core laboratory develops the following capabilities.

  • Detection of sequence variants, and scoring of know sequence variants (mostly SNPs).  The goal is parallel analysis of multiple SNPs in large subject populations.
     
  • Novel approaches in the search of functional polymorphisms in the candidate genes, study of molecular genetic mechanisms, and selection of validated functional polymorphisms for clinical trial, and for use as biomarkers.
     
  • Chemogenomics analysis of large scale drug-gene interaction, usually applied to cancer chemotherapy.
     
  • Bioinformatics support system.  This will provide guidance for investigators to design expression experiments, identify potential SNPs from genomic data, deduce splice variants from ESTS, define candidate genes involved in disease susceptibility and response to drug therapy, etc.
     
  • Medical informatics to integrate genetic/genomic information with clinical data patients

Genotyping panels available to all OSU investigators
        - SNPlex and genotyping panels for high-throughput

Title:  "mRNA expression of membrane transporters and ion channels in the NCI60 cell panel"
Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadee W. Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 64:4294-4301, 2004. 

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